W   67 - 61 

9th-seeded Iowa held a 7-10 point lead most of the game and never trailed in the game, but after a 7-point halftime advantage, Iowa went almost six minutes without scoring while 8th-seeded Clemson pulled within 35-33. Then the Hawks went on a 16-4 run to gain a 14-point lead. But the Tigers rallied to within 61-57 in the closing minutes to make the game tense, but the Hawks made 24 of 31 free throws to close out the game.

Bennett Stirtz led the Hawks with 16 points, but it was the supporting cast that helped Iowa to victory. Kael Combs scored 15 points and Alvaro Foigueiras came off the bench to score 14 points. Iowa's defense was strong, and they held a 40-27 advantage on rebounds, including 15 offensive boards.

It was the first NCAA tournament win over a major conference opponent since 1999 vs Arkansas.

	1	2	F
Iowa	32	35	67
Clemson	25	36	61